Abstract
The usefulness of 1H NMR spectroscopy is illustrated for a detailed study of a selector-solute interactions which maintain enantioseparations in capillary electrophoresis. The apparent binding constants ( K a) of enantiomers and the chemical shift differences at saturation (Δδ c) were calculated using 1H NMR spectroscopy. Some problematic aspects concerning the application of NMR spectroscopy for the explanation of the chiral recognition mechanisms in separation techniques are also shortly discussed. The enantioseparation of a cationic chiral analyte using a cationic cyclodextrin derivative is reported for the first time. This result supports the possibility of enantioseparations in a selector-solute pair carrying the same net charge as recently reported for a negatively charged selector-solute pair.
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