Comparative assessment of complex drugs based on moxidectin and praziquantel for cats endoparasitic invasions

Abstract

The article presents data on the effectiveness of the new domestic antiparasitic drug complex “Moxistop for cats” in comparison to the referenced drug “Vormazol for cats spot-on” used for the treatment and prevention of endoparasitic infestations in cats of different ages, body weights, breeds, and sex. According to the results of parasitological research, animals of the experimental and control groups were found to be spontaneously infected with endoparasites, the causative agents of nematodes: Toxascaris leonina with an intensity of invasion (II) of 110 to 160 eggs in one gram of faeces (EGF) and Uncinaria stenocephala – from 22 to 43 EGF, and the cestode pathogen Taenia pisiformis with the intensity of invasion from 26 to 42 EGF and Dipylidium caninum with the intensity of invasion from 9 to 20 cocoons in one gram of feces (KGF). Before the 7th day and the next seventh–14th day after deworming, helminthocoprological studies were carried out with the definition of parasitological damage indices and determination of the extensive effectiveness (EE) and intensive effectiveness (II) of the drugs. Based on the obtained results, it was found that for spontaneous toxascarose and uncinariasis infestation of cats on the 7th and 14th day after deworming with the drug “Moxistop for cats” and the reference drug “Vormazol for cats spot-on” in doses recommended by the manufacturer, the intensive and extensive effects of the drugs were 100 %. Helminthological studies showed that for spontaneous teniosis-pisiform infestation of cats on the 7th and 14th day after deworming with the experimental drug “Moxistop for cats”, the intensity was 92.2 and 96.8 %, and after deworming with the reference drug “Vormazol for cats spot-on” intensity efficiency was 90.0 and 93.7 %, respectively. It was determined that the intensity of the experimental drug “Moxistop for cats” on the 7th day after deworming was 83.8 % and on the 14th day – 96.0 %, while the intensity of the reference drug “Vormazol for cats spot-on” was on the 7th and 14th day after deworming was 82.9 and 93.3 %, respectively. In general, the results obtained during the therapeutic effectiveness of complex antiparasitic drugs determination indicate that the drugs for nematode infestation of cats can be classified as highly effective (> 98 %) and for cestode infestation of cats – as effective (90–98 %). In vivo field tests have shown that the research drugs are easy to use, well tolerated by animals regardless of age, body weight, breed, and sex, and do not have a toxic effect on the animal's body when they are used by the spot-on method in the recommended by the manufacturer doses.