COMPARATIVE ASSESSMENT OF COMPLEX DRUGS BASED ON MOXIDECTIN AND PRAZIQUANTEL FOR DOG ENDOPARASITIC INVASIONS

Abstract

The article presents data on the effectiveness of the new domestic complex antiparasitic drug «Moxistop for dogs» in comparison with the reference drug «Vormazol for dogs spot-on» that used for the treatment and prevention of endoparasitic infestations in dogs of different breeds, ages and sexes.
 According to the results of parasitological studies, the animals of experimental and control groups were found to be spontaneously infected with endoparasites, the causative agents of nematodes: Toxocara canis with an intensity of invasion (II) from 210 to 250 eggs in one gram of feces, Ancylostoma caninum – from 52 to 80, Trichuris vulpis – from 58 to 85, respectively, and the cestode pathogen Dipylidium caninum – from 20 to 46 cocoons in one gram of feces. Nematodes and cestodosis in dogs were manifested clinically by: deterioration of appetite, depression, paleness of mucous membranes, and in some animals, vomiting and mild diarrhea (unformed feces).
 Before 7th day and during next 7th-14th day after deworming, helminthocoprological studies were carried out with the establishment of indices of parasitological damage and determination of the extensive effectiveness and intensive effectiveness of the drugs.
 Based on the obtained results, it was found that for a spontaneous toxocarosis infestation of dogs on the 7th and 14th day after deworming, the intensity effectiveness (IE) of the experimental drug «Moxistop for dogs» was 96.0 and 98.3%, and the intensity effectiveness of the reference drug «Vormazol for dogs spot-on» – 92.2 and 95.1%, respectively. At the same time, the extensive effectiveness (EE) of both drugs for 7 and 14 days after deworming was 85.7%.
 Helminthological studies showed that for spontaneous hookworm infestation in dogs on 7th and 14th days after the use of the experimental drug and the reference drug in the recommended doses, the intensive and extensive effectiveness of the drugs was 100% in the experimental and control groups of animals.
 In the case of spontaneous trichuria infestation, it was found that on the 7th and 14th day after deworming, the intensity of the experimental drug was 91.7 and 93.1%, and the intensity of the reference drug was 92.8 and 94.2%, respectively.
 At the same time, it was found that for spontaneous dipilidiosis infestation of dogs, the intensity of the experimental drug «Moxistop for dogs» on the 7th day after deworming was 95.1% and on the 14th day – 96.9%, and the intensity of the reference drug «Vormazol for dogs spot-on» on the 7th and 14th day after deworming was 92.9 and 95.8%, respectively.
 Field tests have shown that the research drugs are convenient to use, well tolerated by animals regardless of age, body weight and breed, and do not have a toxic effect on the animal's body when they are used once by the spot-on method in the manufacturer's recommended doses.