Comparativa de diferentes modelos radiómicos para la clasificación de lesiones adrenales indeterminadas diagnosticadas de forma incidental en TC con contraste

Abstract

Purpose: A comparison of different machine learning models to discriminate adrenal incidentalomas by CT studies was performed. Methods: Sixty-two different features were obtained from a sample of 61 incidentalomas using the free license software LIFEx and 19 radiomic studies were performed with different models and feature selection methods to obtain the most efficient determination of possible malignancy. For all of them, four cross-validation methods were evaluated. Adenoma contouring was performed in duplicate by different radiologists evaluating all models in both groups. Results: ROC AUC between 0.42 (0.09-0.81) and 0.92 (0.63-1.00), and accuracy of the models between 0.63 (0.43-0.79) and 0.94 (0.82-1.00). The best-performing model was the balanced logistic regression applied to the 14 features with an intraclass coefficient greater than 0.9, with which accuracy of 0.94 (0.74-1.00), ROC AUC of 0.917 (0.63-1.00), benign recall of 0.92 (0.65-1.00) and malignant recall of 1.00 (0.71-1.00) were obtained. Conclusions: The evaluation and validation of different models has allowed us to obtain an efficient radiomic model for the discrimination of adrenal incidentalomas