Comparação do perfil imunohistoquímico entre mulheres com câncer de mama maiores de 40 e menores de 40 anos

Abstract

Objective: To compare immunohistochemical profiles, such as surrogate molecular classifications of breast carcinomas and histological findings, among women under and over 40 years of age. Methods: This was an observational, quantitative, and retrospective study based on data from the Instituto de Patologia de Araçatuba (IPAT), located in the countryside of the state of São Paulo, Brazil. Pathology reports from biopsy or surgical excision recorded between January 1, 2017, and June 30, 2020 (42 months) were reviewed. Only ductal and lobular carcinomas were histologically analyzed. Age, histological subtype, and immunohistochemical data of estrogen receptor, progesterone receptor, Her-2 and Ki-67 (< 20% x ≥ 20%) were analyzed. Specimens were categorized into two groups based on patient age at diagnosis (≤ 40 years vs. > 40 years). Results: There was no significant difference between the two age groups regarding hormone receptor, Her-2 evaluation, or histological classification (ductal vs. lobular). Nevertheless, breast cancer in younger women was associated with a higher Ki-67 index (p = 0.015). In the group aged 40 years and younger, half of the cases were classified as Luminal B-like, Her-2 negative, and 19% were triple-negative. For women over 40 years old, 57% were classified as luminal B-like, Her-2 negative, 9% were luminal A-like, and only 13% were triple-negative. Conclusion: The frequency of breast among young woman is substantial, and they tend to exhibit higher Ki-67 indexes.