Abstract
Abstract Background: Overactive bladder is an age-related urologic disease. An oxybutynin transdermal patch is used to treat overactive bladder; however, long-term use is not advised because of potential adverse
Highlights
The incidence of overactive bladder (OAB) has increased in Japan because of rapid aging of the population [1]
No significant differences were observed in skin hydration at the lower back area after application of the heparinoid cream; skin hydration in the lower abdomen and femoral areas improved significantly (Figure 3)
We investigated the effect of heparinoid cream application on the outcomes of treatment with an oxybutynin transdermal patch in elderly patients with OAB
Summary
The incidence of overactive bladder (OAB) has increased in Japan because of rapid aging of the population [1]. A major symptom of OAB, decreases the quality of life of patients with OAB [2], therapeutic drugs including muscarinic antagonists and β3-adrenoceptor agonists are administered clinically to improve bladder urine retention. Selective muscarinic antagonists are used as first-line drugs to treat OAB [3] and have been developed as an alternative to oral administration of oxybutynin in order to enhance pharmacotherapeutic tolerance. Production of N-desethyloxybutynin (DEO), an active metabolite of oxybutynin, is lower with transdermal patches than with oral formulations because oxybutynin is absorbed through the skin, thereby avoiding the hepatic first-pass effect [5]. The present study aimed to investigate the advantages of administering a combination of heparinoid cream and oxybutynin transdermal patch treatment for overactive bladder in elderly patients
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