Abstract
Abstract Aim: The purpose of the study was to characterize transdermal delivery of xenon through rat skin from a lipophilic solution and from water. Methods: Sections of skin were obtained from
Highlights
Xenon has been considered an ideal anaesthetic agent due to rapid induction and emergence of anaesthesia, efficient analgesia, and low toxicity [1,2]
Data suggest that blockade of NMDA receptors in the nervous system by xenon plays a key role in neuroprotective effects of this agent [5,8,9,10]
NMDA receptors have been found in the axons of human skin [15] and in the keratinocytes of the epidermis [16,17]
Summary
Sections of skin were obtained from adult rats (n=12) and were placed into static Franz diffusion cells for 24 h. Xenon diffusion coefficients were determined for diffusion from a lipophilic solution (n=6) and from water (n=6) to phosphate buffered saline (PBS) through skin and for diffusion from a lipophilic solution to PBS through a phase boundary in the absence of skin (n=6)
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