Abstract
BackgroundThe collagen 3 alpha 1 (COL3A1) rs1800255 polymorphism has been reported to be associated with women pelvic organ prolapse (POP) susceptibility, but the results of these previous studies have been contradictory. The objective of current study is to explore whether COL3A1 rs1800255 polymorphism confers risk to POP.MethodsRelevant literatures were searched by searching databases including Pubmed, Embase, Google academic, the Cochrane library, China National Knowledge Infrastructure (CNKI). Search time is from database foundation to March 2021.ResultsA total of seven literatures were enrolled in the present meta-analysis, including 1642 participants. Overall, no significant association was found by any genetic models. In subgroup analysis based on ethnicity, significant associations were demonstrated in Caucasians by allele contrast (A vs. G: OR = 1.34, 95%CI = 1.03–1.74,), homozygote comparison (AA vs. GG: OR = 3.25, 95%CI = 1.39–7.59), and recessive genetic model (AA vs. GG/GA: OR = 3.22, 95%CI = 1.40–7.42).ConclusionsThe present meta-analysis suggests that the COL3A1 is a candidate gene for POP susceptibility. Caucasian individuals with A allele and AA genotype have a higher risk of POP. The COL3A1 rs1800255 polymorphism may be risk factor for POP in Caucasian population.
Highlights
Pelvic organ prolapse (POP) is a phenomenon that pelvic organs such as uterus, vagina, bowel and bladder leave out of their normal anatomical location, resulting in a serious of functional disorders [1]
Caucasian individuals with A allele and AA genotype have a higher risk of POP
Positive finding between pelvic organ prolapse and collagen 3 alpha 1 (COL3A1) rs1800255 polymorphism was only found in Caucasian population by allele contrast (A vs. G: OR = 1.34, 95%CI = 1.03–1.74, P = 0.030, Fig 1), homozygote comparison (AA vs. GG: OR = 3.25, 95%CI = 1.39–7.59, P = 0.006, Fig 2), and recessive genetic model (AA vs. GG/GA: OR = 3.22, 95%CI = 1.40–7.42, P = 0.006, Fig 3)
Summary
Pelvic organ prolapse (POP) is a phenomenon that pelvic organs such as uterus, vagina, bowel and bladder leave out of their normal anatomical location, resulting in a serious of functional disorders [1]. It is a very frequent disease in postmenopausal women, especially in senile females [2]. Only approximately 3% women have symptoms of vaginal bulging in some developed countries [4] This wide discrepancy occurs as the majority of POP is symptomless. The objective of current study is to explore whether COL3A1 rs1800255 polymorphism confers risk to POP
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