Ethnicity-stratified analysis of the association between XRCC3 Thr241Met polymorphism and leukemia: an updated meta-analysis

Zhengjun Xie,Wei Cheng,Xin Zhao,Qiuhua Li,Wei Peng

doi:10.1186/s12920-021-01076-w

Abstract

BackgroundPresently, whether X-ray repair cross complementing group 3 (XRCC3) Thr241Met polymorphism is correlated to leukemia risk remains controversial. Because of this reason, the objective of current study is to explore whether XRCC3 Thr241Met polymorphism confers risk to leukemia.MethodsTwo independent authors systematically and comprehensively searched Pubmed, Embase, the Cochrane library, Google academic, China National Knowledge Infrastructure (CNKI). Search time is from database foundation to March 2021.ResultsOverall, significant associations between leukemia risk and XRCC3 Thr241Met polymorphism were found in Caucasian population by allele contrast (T vs. C: OR 1.20, 95% CI 1.02–1.40), homozygote comparison (TT vs. CC: OR 1.35, 95% CI 1.05–1.73), and recessive genetic model (TT vs. TC/CC: OR 1.31, 95% CI 1.04–1.64).ConclusionsThe present meta-analysis suggests that the XRCC3 Thr241Met polymorphism may be a risk factor for leukemia in Caucasian population.

Highlights

Whether X-ray repair cross complementing group 3 (XRCC3) Thr241Met polymorphism is correlated to leukemia risk remains controversial
As far as we know, this is the first meta-analysis which comprehensively explores the association between XRCC3 Thr241Met polymorphism and leukemia susceptibility
Different genotyping methods were used such as direct sequencing, PCR–Restricted fragment length polymorphism (RFLP) and TaqMan

Summary

Introduction

Whether X-ray repair cross complementing group 3 (XRCC3) Thr241Met polymorphism is correlated to leukemia risk remains controversial. Because of this reason, the objective of current study is to explore whether XRCC3 Thr241Met polymorphism confers risk to leukemia. Leukemia is a very frequent malignance tumor originating from hematopoietic stem cells. The leukemia cell stops at different stages of cell development due to uncontrolled proliferation, dysdifferentiation and aleukemiatosis block. The incidence of leukemia in China is approximately 3–8 individuals per 100,000 [1, 2]. About One hundred thousand people are diagnosed with leukemia every year [2]. There is no doubt that the occurrence of leukemia brings a huge burden on individuals, families, and health care systems.

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Discussion

Conclusion