Cognitive function of women in menopausal transition: MHT effects

Abstract

Increasing in count of middle-aged and elderly people is setting a new direction for the development of medicine. The popular anti-age therapy is aimed at preventing the development and effective treatment of age-associated diseases. For female body the aging process is primarily associated with sex steroids production decreasing. Deterioration of cognitive activity affecting patients' ability to work and social involvement in perimenopausal period. A large number of estrogen and progesterone receptors have been found in different parts of the CNS. These receptors respond to signaling cascades triggered by hormones better during the period of primary estrogen deficiency, which determines the critical window period. Acting from this position, we studied 120 perimenopausal patients, who were divided into four groups: The first, the second and the third groups received different types of MHT, the fourth (control) group didn’t receive any treatment. All participants underwent clinical, laboratory and instrumental examination at the beginning and after 360 days of research. Our results demonstrated the efficacy of early start hormonal therapy to improve the cognitive abilities of women during the menopausal transition.