Abstract
Phytochemicals from Coffea arabica plant extract are traditionally used to cure conjunctivitis. It is caused by Haemophilus influenza. Molecular docking method applied using “Biovia Discovery Studio”. “High positive values of -CDOCKER energy and -CDOCKER interaction energy” suggested that caffeine and chlorogenic acid can efficiently deactivate the shikimate dehydrogenase enzyme which will result in interruption of the life cycle of the microorganism.
Highlights
IntroductionHerbal derived remedies need a powerful and deep assessment of their pharmacological extracts derived from different parts show antimicrobial activity against different microorganisms [2]
Plants are the valuable resources of new drugs [1]
-CDOCKER energy was calculated based on the internal ligand strain energy and receptor-ligand interaction energy. -CDOCKER interaction signifies the energy of the nonbonded interaction that exists between the protein and the ligand
Summary
Herbal derived remedies need a powerful and deep assessment of their pharmacological extracts derived from different parts show antimicrobial activity against different microorganisms [2]. Traditional medicines are given importance to treat different diseases [3]. Coffea arabica L belongs to family Rubiacea. Coffea arabica L extract is used to cure diseases like conjunctivitis. The objective of the study is to identify the phytochemical responsible to cure the disease. Coffea arabica L contains “cafestol, caffeine, chlorogenic acid and triglycerides” etc. This objective of the study is to identify the phytochemical of Coffea arabica L capable of curing conjunctivitis
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