Abstract

Carbon Dioxide transoral laser microsurgery represents a reliable option for the treatment of early glottic carcinoma (Tis–T2), with good functional and oncological outcomes, nowadays representing one of the main options in larynx preservation protocols. The development and improvement of laser devices means surgeons are able to use more precise instruments compared with classic cold dissection in laser-assisted phonosurgery. Secondary effects on voice, swallowing, or quality of life as well as complications have been well documented. Also, with the introduction of a new proposal for staging systems following the principle of the three-dimensional map of isoprognostic zones, the use of narrow-band imaging in clinical evaluation and intraoperative, and the implementation of diffusion-weighted magnetic resonance during preoperative evaluation, the development of new tools to improve surgical quality and preliminary reports regarding the use of carbon dioxide laser in transoral robotic surgery suggests an exciting future for this technique.

Highlights

  • Laryngeal squamous cell carcinoma (LSCC) is a common malignancy, representing 30%–50%of all neoplasms in the head and neck, with 157,000 new cases diagnosed worldwide in 2012 [1].The management of early stage (Tis, T1, T2) laryngeal cancer (Supraglottic, Glottic, and Subglottic) has evolved over the last 40 years from the classic open surgical resection techniques to a less aggressive and more functional endoscopic approach due to the evolution of surgical strategies, diagnostic workup, and follow-up protocols

  • The main advantage of transoral laser microsurgery remains in the possibility of minimizing the area of the larynx, which is resected during the surgery, preserving more healthy tissue and optimizing the patient’s recovery, airway management, as well as post-surgical voice without compromising their overall survival [3]

  • Due to its wavelength (10,600 nm), the CO2 Laser is absorbed by water, allowing very predictable cutting and an ablation mode with an optical penetration that is limited to tissues

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Summary

Introduction

Laryngeal squamous cell carcinoma (LSCC) is a common malignancy, representing 30%–50%. The management of early stage (Tis, T1, T2) laryngeal cancer (Supraglottic, Glottic, and Subglottic) has evolved over the last 40 years from the classic open surgical resection techniques to a less aggressive and more functional endoscopic approach due to the evolution of surgical strategies, diagnostic workup, and follow-up protocols. CO2 Laser Surgery of the Larynx has gained followers around the world during these four decades, becoming the gold standard for almost all early stage cancer (Tis–T2). This is the reason why in this review, the authors try to summarize and expose the most relevant concepts about the technique

General Aspects and Physical Properties
Brief History of CO2 Laser of the Larynx
Classification Systems
Evidence in Benign and Premalignant Lesions
Evidence in Malignant Pathology
Anterior Commissure
Subglottal Extension
Resection Margins
Margin Size
How to Classify Margin Involvement
Handling of Positive or Inadequate Margins
Recurrence Rate
Second Look
Salvage CO2 TOLMS
Functional Outcomes After Laser Surgery of the Larynx
Voice Outcome
Swallowing Outcome
Tracheostomy
Quality of Life
Complications
10. Limitations of CO2 TOLMS
11.1. Narrow Band Imaging
11.2. New Laser Devices
11.3. The Imaging as a Way to Improve Our Results
11.5. The Laser and the Robot
11.6. Computer Assisted Laser Surgery of the Larynx
11.7. The Laryngoscore
Findings
12. Conclusions

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