Abstract
Objective To investigate and explore the clinical value of single-photon emission computed tomography(SPECT) imaging in the differential diagnosis of neonatal obstructive jaundice. Methods From January 2012 to April 2017, 130 cases of suspected neonatal obstructive jaundice in the First Hospital of Jiaxing were enrolled in the study.All patients were given SPECT hepatobiliary scintigraphy, were injected 99mTc-EHIDA imaging agent, 99mTc-MIBI imaging agent, diagnosis of hepatobiliary scintigraphy after the acquisition.The result of operative cholangiography was viewed as the gold standard, the diagnostic sensitivity, specificity, accuracy of simple 99mTc-EHIDA SPECT imaging examination, combined with SPECT imaging agent in the diagnosis of neonatal obstructive jaundice were calculated and compared.The coincidence rate of differential diagnosis of different etiologies of neonatal obstructive jaundice was also compared. Results The diagnostic sensitivity, specificity and accuracy of combined with SPECT imaging agent in the diagnosis of neonatal obstructive jaundice were 94.23%, 96.15%, 94.61%, respectively, which of simple 99mTc-EHIDA imaging agent SPECT were 83.65%, 76.92%, 82.31%, respectively, the differences were statistically significant(χ2=5.915, 4.127, 9.646, all P<0.05). The coincidence rates of extrahepatic biliary atresia, hepatitis syndrome of the two kinds of SPECT imaging agents combined examination were 96.05%, 96.43%, respectively, which were significantly higher than those of the 99mTc-EHIDA imaging agent SPECT examination (84.21%, 85.00%)(χ2=5.991, 5.250, all P<0.05). Conclusion SPECT imaging in the diagnosis of neonatal obstructive jaundice has high sensitivity and accuracy, especially in combination with 99mTc-EHIDA imaging agent, 99mTc-MIBI imaging agent can identify and distinguish different causes of jaundice, and provide a reliable basis for clinical treatment. Key words: Jaundice, neonatal; Jaundice, obstructive; Diagnosis; Single-photon emission computed tomography
Published Version
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