Clinical value of circulating tumor cells in tumor reflux venous blood in colorectal cancer patients with liver metastasis

Abstract

Objective To investigate the significance of circulating tumor cells in tumor reflux venous blood in colorectal cancer patients with liver metastasis. Methods Seventy-four patients with colorectal cancer treated in Liaoning Cancer Hospital & Institute from January 2015 to January 2017 were enrolled in this study.The circulating tumor cells were detected by CellSearch system in patients with tumor reflux venous blood to analyze the results of circulating tumor cells and their clinical significance. Results Among the 74 patients with colorectal cancer, there were 24 patients with synchronous liver metastasis and 9 patients with metachronous liver metastasis.The sensitivity of CEA and CA19-9 positive in the detection of colorectal cancer synchronous liver metastasis was 67.9% and 58.6%, respectively.The sensitivity of circulating tumor cells positive detection in tumor reflux venous blood in the diagnosis of synchronous liver metastasis was 60.6%.n patients with metachronous liver metastases, CEA and CA19-9 positive patients were 33.3% and 55.6%, respectively, while CTCs positive patients were 77.8%. Conclusion The detection of circulating tumor cells in tumor reflux venous blood of colorectal cancer not only improves the detection rate, but also may become a predictive factor for metachronous liver metastasis. Key words: Tumor Reflux Venous Blood; Circulating Tumor Cells; Colorectal Cancer; Liver Metastasis