Abstract
Objective To investigate the relationship between expression of CCL2 in the primary colorectal cancer and synchronous liver metastasis. Methods Clinicopathological data of 197 cases with colorectal cancer from Jan.1999 to Dec.2003 in Department of Abdominal Surgery, Cancer Hospital(Institute), CAMS was retrospectively reviewed.104 cases of colorectal cancer without recurrence in 5 years and 93 cases with synchronous liver metastasis were included.The expression of CCL2 was tested in the paraffin primary tumors by immunohistochemistry.The correlation between liver metastasis and clinicopathological factors including CCL2 was done by univariate and multivariate analysis. Results Tumor size, lymph node, CEA and CCL2 were independent factors in multivariate analysis(P 0.05). Conclusion The close relationship of tumor size, lymph node, CEA and CCL2 between synchronous colorectal cancer liver metastasis was confirmed.The mechanism of CCL2 underlies the colorectal liver metastasis maybe different from the other clinicopathological factors. Key words: Colorectal neoplasm; Neoplasm Metastasis; Chemokine CCL2; Pathology, Clinical
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