Clinical Study on traditional Chinese medicine treatment of CSG and its impact on MTL, GAS and SS

Abstract

Objective To discuss of the therapeutic effects of treating three TCM types of Chronic superficial gastritis （CSG）disharmony of liver and stomach, weakness of the spleen and the stomach, and damp heat in the spleen and the stomach with chinese medicine, and to discuss its impact on the changes of three gastrointestinal hormones-- motilin （MTL）, gastrin （GAS）, and somatostatin （SS）. Methods The data of 150 CSG patients in Shenzhen Bao’an Hospital from Feb, 2011 to Mar, 2013 were selected. These patients belonged to three kinds of syndrome, which was disharmony of liver and stomach, weakness of the spleen and the stomach, and damp heat in the spleen and the stomach, each syndrome had 50 cases. Different Chinese medicines were applied to different syndrome of patients. After one month treatment, the therapeutic effects and the changes of MTL, GAS, SS in these patients were detected by radioimmunoassay. Results After treatment, the total effective rate of the damp heat in the spleen and the stomach syndrome was 94%, the weakness of the spleen and the stomach type was 88%, disharmony of liver and stomach type was 90%, the difference was not statistically significant among the three types（χ2=3.84, P〉0.05）;after treatment, the serum MTL, SS level of disharmony of liver and stomach, weakness of the spleen and the stomach, and damp heat in the spleen and the stomach type were [damp heat in the spleen and the stomach type were （240.25±7.29）pg/ml, （68.23± 5.97）pg/ml;the weakness of the spleen and the stomach type were （260.16±8.84）pg/ml, （75.35±4.65）pg/ml;disharmony of liver and stomach type were（258.32±15.23）pg/ml, （80.12±7.88）pg/ml] higher than before treatment [damp heat in the spleen and the stomach type were （87.26±7.58）pg/ml, （49.34±4.93）pg/ml;the weakness of the spleen and the stomach type were （67.11±7.81）pg/ml, （57.15±5.11）pg/ml; disharmony of liver and stomach type were （89.26±7.60）pg/ml, （40.63±7.26）pg/ml], and the levels of serum GAS＆amp;nbsp;[（156.38±17.36）pg/ml, （146.15±15.56）pg/ml, （140.26±13.37）pg/ml] was lower than before treatment [（274.59 ± 17.82）pg/ml, （320.83 ± 15.02）pg/ml, （216.15 ± 13.77）pg/ml], the difference was statistically significant （P〈0.05 or 0.01）. Conclusions The changes of three hormones-MTL, GAS, SS can be used as an objective basis for the diagnosis and the judgment of healing efficacy of CSG treated by traditional Chinese medicine. Key words: Chronic superficial gastritis; Motilin; Gastrin; Somatostatin; Traditional chinese medicine treatment