Clinical study on the Xingshen-Kaiqiao acupuncture combined with salviae miltiorrhizae and ligustrazine hydrochloride injection for acute cerebral infarction

Abstract

Objective To evaluate the efficacy of Xingshen-Kaiqiao combined with salviae miltiorrhizae and ligustrazine hydrochloride injection in the treatment of acute cerebral infarct (ACI). Methods A total of 142 patients with ACI meeting the inclusion criteria were randomly divided into 2 groups, with 71 cases in each group. The control group received intravenous injection of salviae miltiorrhizae and ligustrazine hydrochloride injection on the basis of routine treatment, and the observation group was given Xingshen-Kaiqiao acupuncture method on the basis of the control group. After treatment of ed with 14 days, the enzyme linked immunosorbent assay was used to detect the central nervous specific protein (S100β) was detected by the enzyme linked immunosorbent assay, the level of homocysteine (Hcy) was detected by circulating enzyme method. T, the level of hypersensitive C-reactive protein (hs-CRP) was detected by immunization turbidimetry, and the automatic coagulant was used to detecded the D-Dimer (D-D) and antithrombin Ⅲ (AT Ⅲ) levels by the automatic coagulant. The degree of nerve function defect in patients were evaluated using the National Institute of Health Stroke Scale (NIHSS), and the daily living ability of the patients by the improved barthel index (MBI) were evaluated, and the clinical efficacy was also observed. Results The total effective rate of the observation group was 97.2% (69/71), and the total effective rate of thecontrol group was 88.7% (63/71), with the difference showing statistically significant (χ2=3.873, P=0.049). The score of 7 d (6.1 ± 1.9 vs. 8.2 ± 2.1, t=2.520), 14 d (3.8 ± 1.1 vs. 6.2 ± 1.8, t=2.712) of the observation group were significantly lower than that those of the control group (P<0.05); ). The MBI scores after 7 d and 14 d were respectively (77.7 ± 8.1 vs. 64.1 ± 7.1, t=2.803) and 14 d and (83.2 ± 9.1 vs. 76.5 ± 7.8, t=4.014) of the observation group were significantly higher than those of the control group (P<0.05); ). After the treatment, the D-D (0.79 ± 0.33 g/ml vs. 1.22 ± 0.37 g/ml, t=4.221), Hcy (13.46 ± 2.89 μmol/L vs. 18.33 ± 3.09 μmol/L, t=5.692), hs-CRP (12.85 ± 3.23 mg/L vs. 18.65 ± 4.13 mg/L t=5.279), the S100β (91.63% ± 5.06% vs. 83.05% ± 4.87%, t=6.086) of the observation group were significantly higher than those of the control group (P<0.01). Conclusions The combination of Xingshen-Kaiqiao acupuncture method and salviae miltiorrhizae and ligustrazine hydrochloride injection can improve the level of anticoagulant factor in the patients, and reduce the inflammatory response in the infarct area and promote the recovery of nerve. Key words: Brain infarction; Acupuncture therapy; Consciousness-restoring resuscitation; Salviae miltiorrhizae and ligustrazine injection