Abstract

Objective To observe the effect of recombinant tissue plasminogen activator (rt-PA) on neurological function and prognosis in patients with acute ischemic stroke (AIS). Methods The clinical data of 166 patients with acute cerebral infarct (ACI) admitted to our hospital from January, 2017 to June, 2018 were retrospectively analyzed. According to the treatment methods, they were divided into a control group and an observation group, 83 cases for each group. The control group was given routine treatment for AIS. The observation group was given early rt-PA thrombolysis on the basis of routine treatment (within 4.5 hours of onset). The efficacies and prognosis of the two groups were compared. The score changes in the National Institutes of Health Stroke Scale (NIHSS) were observed. Results The total effective rate of the observation group was higher than that of the control group (P 0.05). There was no statistical difference in the NIHSS score between the two groups before the treatment (P>0.05). The scores of NIHSS 24.0 h and 14 d after thrombolysis were lower in the observation group than in the control group (both P<0.05). Conclusion Early rt-PA thrombolysis is effective and safe in the treatment of ACI, which can effectively improve the patients’ neurological function and prognosis. Key words: Acute ischemic stroke; rt-PA; Neurological function; Prognosis

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