Clinical study on addition treatment of liver-kidney yin deficiency and postmenopausal osteoporosis with Liuwei Dihuang pill

Abstract

Objective To study the clinical effects of addition treatment of liver-kidney yin deficiency and postmenopausal osteoporosis with Liuwei Dihuang pill. Methods 120 patients suffering from postmenopausal osteoporosis who were determined to be subject to liver-kidney Yin deficiency by doctors of traditional Chinese medicine when they received treatment at the outpatient clinic of traditional Chinese medicine department of our hospital in the period from February 2010 to june 2013 were divided into three groups: group A,B and C,with the random number table.For group A:provided the honeyed pills made up by supplemented six-ingredient rehmannia pill,and taken two pills per day continuously for six months; For group B:provided 5mg of zoledronic acid injection for intravenous drip infusion;For group C:provided traditional Chinese medicine honeyed pills and zoledronic acid for treatment at the same time; all of the three groups take Calcium carbonate D3 at the same time;The three groups of cases until the 12th month were observed and followed-up. The clinical efficacy of three groups were compared. Results A,C group 3 months after treatment with estradiol levels compared with before treatment, the difference was statistically significant(t=2.54,P=0.05,t=2.07,P=0.06). A group 3 months after treatment,the VAS scores at 6 months respectively(3.75±1.32),(2.06±1.53)points before treatment, and the differences were statistically significant(t=10.18, P=0.00,t=9.26,P=0.00). A group 3 months after treatment,the SF-36 scores at 6 months were(90.82± 12.38),(105.82±9.06)%respectively, compared with that before treatment, the differences were statistically significant(t=8.40,P=0.00,t=5.21,P=0.00).A group 6 months after treatment of lumbar 1-4 bone densitywere (0.85±0.07)g/m2,and before treatment[(0.76±0.07)g/m2]comparison,thedifference was statistically significant(t =7.5 6,P=0.0 0);A group 6 months after treatment of Wards bone density com pared with before treatment, the difference was statistically significant(t=8.07,P=0.00).C group 6 months after treatment of lumbar 1-4 bone density(0.91±0.07)g/m2,and B Group[(0.88±0.05)g/m2]comparison,the difference was statistically significant(t=27.19,P=0.00);C group after treatment,the bone mineral density of Wards area for 6 months were(0.62±0.04)g/m2.The difference was statistically significant(t=26.22,P=0.00), compared with the B group.The TCM syndromes of TCM in the 6 months after treatment in A group were(5.42± 2.13),and the difference was statistically significant(t=13.29,P=0.00),compared with the B Group(10.75 ±4.08).(t=13.29,P=0.00). Compared with B group,the difference was statistically significant(t=26.22,P =0.00).A group after the treatment of TCM syndrome score was 6 months(5.42±2.13),and B Group[(10.75 ±4.08)],the difference was statistically significant(t=13.29,P=0.00). Conclusion The addition of Liuwei Dihuang pill can improve BMD, alleviate the ostealgia and improve life quality of patients suffering from postmenopausal osteoporosis, and has no obvious adverse effects. It can enhance curative effects through using with diphosphonate. Key words: Osteoporosis; Yin deficiency; Bone density; Liuwei dihuang pill