Abstract
Objective To investigate the effect of poractant alfa injection(PS)on neonatal respiratory distress syndrome(NRDS). Methods According to the digital table, 80 cases of NRDS were randomly divided into the control group (40 cases)and the treatment group(40 cases). Both two groups were treated by mechanical ventilation and conventional symptomatic, supportive treatment. The treatment group was given PSintratracheal injection, the control group was given 0.9% sodium chloride injection intratracheal injection. The clinical symptoms, blood gas analysis and the improvement of X- ray chest film were dynamicly observed, the clinical efficacy was compared between the two groups. Results In the treatment group, PaO2 returned to> 60mm Hg time, PaCO2 returned to< 50mm Hg time, mechanical ventilation time were(2.13±0.21)h,(12.56±0.11)h,(18.2±0.33)h,which were shorter than those in the control group[(12.41±0.13)h,(89.87±0.26)h,(76.13±0.65)h,t= 2.632,2.403,1.895,all P<0.05]; 39 cases in the treatment group were cured(97.5%),30 cases in the control group were cured(75.0%), the difference of cure rate between the two groups was statistically significant(χ2= 8.53,P<0.05). The incidence rate of complications such as pulmonary hemorrhage, pneumothorax, intracranial hemorrhage in the treatment group was 7.5%, which was significantly lower than 32.5% in the control group(χ2= 7.81,P<0.05). Conclusion PS in the treatment of NRDS has obvious curative effect and less adverse reactions, it can be used in clinical application. Key words: Poractant alfa injection; Newborn; Respiratory distress syndrome; Clinical study
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