Clinical study of lactobacillus acidophilus combined with glutathione in the treatment of nonalcoholic fatty liver disease

Abstract

Objective To investigate the clinical effects of lactobacillus acidophilus combined with glutathione in the treatment of nonalcoholic fatty liver disease. Methods 120 patients with nonalcoholic fatty liver disease were selected, and they were randomly divided into control group (60 patients used glutathione alone) and observation group (60 patients received lactobacillus acidophilus on the basis of control group). The clinical efficacy, liver function index, blood lipid index and the ultrasonography grading of fatty liver before and after treatment of the two groups were compared. Results The clinical total effective rates of the control group and the observation group were 76.67%, 91.67%, respectively.The total effective rate of the observation group was significantly higher than that of the control group(χ2=10.52, P<0.05). The levels of AST, ALT and GGT of the observation group after treatment were significantly lower than those of the control group and before treatment[(36.89±7.14)U/L, (36.89±7.14)U/L, (36.89±7.14)U/L vs.(49.36±11.08)U/L, (45.91±10.24)U/L, (90.28±20.70)U/L; (36.89±7.14)U/L, (36.89±7.14)U/L, (36.89±7.14)U/L vs.(92.90±24.3)U/L, (81.11±17.37)U/L, (147.27±34.19)U/L, t=2.88, 2.54, 2.91; 3.01, 3.36; 3.18, 3.48; 3.41, 3.87; all P<0.05). The levels of TG, TC, HDL-C and LDL-C of the observation group after treatment were significantly better than those of the control group and before treatment[(1.66±0.42)mmol/L, (4.05±0.77)mmol/L, (1.69±0.60)mmol/L, (2.44±0.38)mmol/L vs.(2.13±0.80)mmol/L, (4.64±0.94)mmol/L, (1.45±0.48)mmol/L, (2.97±0.57)mmol/L; (1.66±0.42)mmol/L, (4.05±0.77)mmol/L, (1.69±0.60)mmol/L, (2.44±0.38)mmol/L vs.(2.71±1.33)mmol/L, (5.42±1.27)mmol/L, (1.08±0.36)mmol/L, (3.49±0.71)mmol/L, t=2.43, 2.13, 2.55, 2.07; 3.02, 3.41; 3.11, 3.65; 2.81, 3.30; 2.87, 3.15; all P<0.05). In the control group, normal in 6 cases, mild in 24 cases, moderate in 21 cases and severe in 9 cases as fatty liver degree; in the observation group, normal in 13 cases, mild in 30 cases, moderate in 13 cases and severe in 4 cases as fatty liver degree.The ultrasonography grading of fatty liver of the observation group after treatment were significantly better than those of control group and before treatment(U=3.74, 5.20, all P<0.05). Conclusion Lactobacillus acidophilus combined with glutathione in the treatment of nonalcoholic fatty liver disease can efficiently promote the recovery process of liver function, regulate blood lipid levels and is helpful to improve the imaging grading. Key words: Actobacillus acidophilus; Glutathione; Nonalcoholic fatty liver disease; Clinical effects