Clinical study of high-frequency oscillatory ventilation in the treatment of pulmonary hemorrhage in newborn infants

Abstract

Objective To investigate the effects of high frequency oscillatory ventilation in the treatment of neonatal pulmonary hemorrhage curative. Methods 56 neonates with pulmonary hemorrhage were selected, 28 cases in high frequency mechanical ventilation(HFOV) group and 28 cases in conventional mechanical ventilation(CMV) group.On the basis of conventional treatment, the HFOV group received high-frequency mechanical ventilation therapy, the CMV group treated with conventional ventilation.The breathing machine parameters of the two groups were observed and recorded, calculated oxygenation index(OI) and arterial/alveolar oxygen partial pressure ratio(a/APaO2). The duration of pulmonary hemorrhage, the duration of mechanical ventilation, the length of hospital stay, and the duration of oxygen therapy were compared between the two groups. Results Before treatment, there were no statistically differences of in OI and a/APaO2 between the two groups(t1=0.28, P1=0.78; t2=0.47, P2=0.64), 1h treatment later, declining value of the OI and the rising of a/APaO2 in surviving children, and the therapeutic effect of the HFOV group were more obvious than those of the CMV group(t1′=2.14, P1′=0.04; t2′=2.26, P2′=0.03). In the HFOV group, 23 cases cured(82.1%), 5 cases died(17.9%). And in CMV group, 15 cases cured(53.6%), 13 cases died(46.4%). The duration of pulmonary hemorrhage, the duration of mechanical ventilation, the length of the hospital stay, and the duration of oxygen therapy of the HFOV group were significantly lower than those of CMV group, the differences were statistically significant(P=0.046, 0.044, 0.048, 0.035). Conclusion HFOV can better improve oxygenation function in infants with pulmonary hemorrhage, shorten the course of the disease and improve the cure rate, recommend the application and clinical treatment. Key words: High-frequency ventilation; Acute lung injury; Hemorrhage; Infant, newborn