Abstract
ObjectiveTo explore the efficacy and safety of high-frequency oscillatory ventilation (HFOV) in the treatment of severe meconium aspiration syndrome (MAS) complicated with severe acute respiratory distress syndrome (ARDS).MethodsA total of 65 infants with severe MAS complicated with severe ARDS were included in the study. The clinical efficacy of treatment for the HFOV group (n = 31) and the conventional mechanical ventilation (CMV) group (n = 34) was retrospectively analysed. The partial pressure of oxygen (PaO2), partial pressure of carbon dioxide (PaCO2), PaO2/fraction of inspired oxygen (FiO2), and oxygen index values before and at 6, 12, 24, 48, and 72 h after mechanical ventilation, the mechanical ventilation time, oxygen inhalation time, incidence of complications, and outcomes of the two groups were compared.ResultsAt 6, 12, 24, and 48 h after mechanical ventilation, the PaO2 in the HFOV group was significantly higher than in the CMV group, while the PaCO2 in the HFOV group was significantly lower than in the CMV group (P < 0.05). At 6, 12, 24, 48, and 72 h after mechanical ventilation, PaO2/FiO2 in the HFOV group was significantly higher than in the CMV group, and the OI in the HFOV group was significantly lower than in the CMV group (P < 0.05). Mechanical ventilation time, oxygen inhalation time, and the incidence of air leakage were significantly lower in the HFOV than in the CMV group (P < 0.05).ConclusionsOverall, HFOV can effectively improve lung ventilation and oxygenation function, shorten ventilator treatment time, and reduce the incidence rate of air leakage for neonatal MAS, making it a safe and effective treatment option.
Highlights
Neonatal meconium aspiration syndrome (MAS) is a type of postnatal dyspnoea resulting from the inhalation of meconium-contaminated amniotic fluid in utero or during delivery [1]
As a serious lung disease caused by meconium, MAS leads to airway obstruction and, Yang et al BMC Pediatrics (2021) 21:560 subsequently, pulmonary surfactant (PS) inactivation, chemical pneumonia, and persistent pulmonary hypertension of the newborn (PPHN) [2]
Severe MAS is often complicated by acute respiratory distress syndrome (ARDS), which leads to additional severe clinical symptoms, making treatment more difficult and increasing the fatality rate [4]
Summary
Neonatal meconium aspiration syndrome (MAS) is a type of postnatal dyspnoea resulting from the inhalation of meconium-contaminated amniotic fluid in utero or during delivery [1]. As a serious lung disease caused by meconium, MAS leads to airway obstruction and, Yang et al BMC Pediatrics (2021) 21:560 subsequently, pulmonary surfactant (PS) inactivation, chemical pneumonia, and persistent pulmonary hypertension of the newborn (PPHN) [2]. In China, the mortality rate of infants with MAS is 7.0%–15.8% [3]. Severe MAS is often complicated by acute respiratory distress syndrome (ARDS), which leads to additional severe clinical symptoms, making treatment more difficult and increasing the fatality rate [4]. For uneven ventilation with partial alveolar collapse and excessive expansion, conventional mechanical ventilation (CMV) often fails to achieve the anticipated clinical effect. Compared with CMV, high-frequency oscillatory ventilation (HFOV) has the advantages of low tidal volume, low airway pressure, and reduced alveolar injury; it is an ideal means of lung-protective ventilation
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
