Clinical study of Ginkgo biloba capsule combined with isosorbide mononitrate in treating angina pectoris of coronary heart disease

Abstract

Objective To explore the clinical effect of Ginkgo biloba capsule combined with isosorbide mononitrate in the treatment of angina pectoris of coronary heart disease. Methods From April 22, 2017 to April 22, 2018, 100 patients with coronary heart disease and angina pectoris admitted to Zhoushan Traditional Chinese Medicine Hospital were enrolled in the study.Fifty patients in the control group were treated with isosorbide mononitrate.Fifty patients in the observation group were treated with Ginkgo biloba capsules and isosorbide mononitrate.The left ventricular end-diastolic diameter (LVEDD), left ventricular end-systolic diameter (LVESD), left ventricular ejection fraction (LVEF), duration of angina pectoris, frequency of angina attacks, total effective rate, incidence of adverse reactions, angina relief time were observed. Results The LVEDD, LVESD, LVEF, total effective rate, incidence rate of adverse reaction, duration of angina pectoris, angina pectoris frequency and angina pectoris remission time in the observation group were (48.41±2.23)mm, (30.89±1.12)mm, (56.55±5.87)%, 96.00%, 4.00%, (3.44±1.52)min/time, (1.36±0.54)times/week, (3.12±0.56)min, respectively, which were better than those in the control group [LVEDD (64.78±2.89)mm, LVESD (42.21±1.55)mm, LVEF (43.46±1.52)%, total effective rate (74.00%), incidence rate of adverse reactions (28.00%), duration of angina pectoris (5.68±1.66)min/time, frequency of angina pectoris (2.68±1.47)times/week, angina relief time (4.87±1.41)min] (t=19.546, 41.857, 15.264, χ2=9.490, 10.714, t=7.037, 5.960, 8.156, all P<0.05). Conclusion Ginkgo biloba capsule combined with isosorbide mononitrate is effective in the treatment of patients with coronary heart disease and angina pectoris. Key words: Coronary artery disease; Angina pectoris; Cardiac output; Ginkgo biloba capsule; Isosorbide mononitrate