Abstract
Objective To observe the safety and efficacy of rocuronium rapid sequence induction in patient undergoing laparoscopic cholecystectomy(LC). Methods 100 patients undergoing laparoscopic cholecystectomy were randomly divided into two groups(n=50):control group(group C)and rocuronium rapid sequence induction group (group R).Conventional induction of anesthesia was used in group C,rocuronium rapid sequence induction was used in group R and assisted ventilation was not implemented in the induction process. Oxygen saturation(SpO2), partial pressure of oxygen(PaO2), carbon dioxide partial pressure(PaO2),p H were recored at the condition of breathing air(T0), breathing pure oxygen 5 minutes(T1), after intubation(T2)and mechanical ventilation five minutes(T3). The grade of the exposure in operation field, the operative time, indwelling of gastric suction tube, the time of no ventilation in group R were recorded, too. Results Compared to T1 time point, PaO2 and pH in group R decreased, but PaCO2 was significantly higher at T2 time point(P 0.05),but SpO2 and PaO2 were higher than preoperative at every time point(P<0.05).The incidence of Indwelling gastric suction tube is higher in group C than in group R,the grade of exposure in the operation field were better in group R than in group C(P<0.05). Conclusion Application of rocuronium rapid sequence induction technique in laparoscopic cholecystectomy can improve the operative conditions and field, it can be safely used in clinical anesthesia. Key words: Rocuronium; Anesthesia technique; Laparoscopic cholecystectomy
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