Abstract
Objective To investigate the clinical value of peripheral blood T lymphocyte subset and serum C-reactive protein(CRP) and procalciton(PCT) for diagnosis and therapy in elderly asthma patients.Methods The difference of T lymphocyte subset was compared between 45 elderly asthma patients and 50 young and middle-aged asthma patients.The changes of CRP and PCT levels before and after therapy were compared in 45 patients with elderly asthma.Results The expression of CD3+,CD4+,CD8+,CD19+ and natural killer(NK) cell in elder patients were lower than the control group( all P ＜ 0.05 ),while CD4/CD8+ was higher( P ＜ 0.01 ).The levels of CRP and PCT were significantly lower after therapy than that before therapy (P ＜ 0.01 ).Conclusion The cytoimmunity and humoral immune function of elderly was decreased.The acute attack or exacerbation of asthma was related with infection.The detection of CRP and PCT could determine infection.CRP should be an sensitive marker to reflect infection,while PCTwas also a prognostic indicator. Key words: Asthma; T-Lymphocytes ; C-Reactive protein; Calcitonin; Aged
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