Abstract
Clinical Significance of microRNA Polymorphisms and Expression Profiles in Oral Cancer Development
Highlights
Head and neck cancers are the sixth most prevalent and, many a times, most preventable type of cancer in the world and one of the leading causes of death in developing countries [1,2]
Ambrose et al proposed a new mechanism of microRNA(miRNA)-mediated transcriptional regulation that could promote cancer development [11]. miRNA has been another hotspot in cancer research in recent years [12,13]
Since most of the miRNA genes are found to be located in cancer-related chromosomal regions functioning either as oncogenes or tumor suppressor genes; single nucleotide polymorphisms (SNPs) in these genes could be the most common form of variations present in the human genome
Summary
Head and neck cancers are the sixth most prevalent and, many a times, most preventable type of cancer in the world and one of the leading causes of death in developing countries [1,2]. Since most of the miRNA genes are found to be located in cancer-related chromosomal regions functioning either as oncogenes or tumor suppressor genes; single nucleotide polymorphisms (SNPs) in these genes could be the most common form of variations present in the human genome.
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