Clinical significance of detecting cardiac troponin I and CK-MB in children with hand-foot-and-mouth disease

Abstract

Objective To investigate the clinical significance of detecting cardiac troponin I(cTnI)and CKMBin children with hand- foot- and-mouth disease and myocardial injury. Methods 90 children with hand-footand-mouth disease(observation group) were detected the level of serum c TnI and CK- MB. At the same time,40 healthy children were chosen as control group. Results Compared with the control group, the levels of CK- MB and cTnl in observation group were significantly higher than those of the control group(t= 8.92,5.46,all P< 0.01), which indicated that children with hand, foot and mouth disease was easier to merge myocardial injury. CK-MB and c Tnl levels in high-risk group were significantly higher than those in normal children group(t= 9.17,6.13,all P< 0.01), and the levels of CK- MB and cTnl were positively correlated with severe degree(r= 0.767,0.683,all P<0.01). For children with hand,foot and mouth disease merged myocarditis,cTnl diagnostic sensitivity(53.8%)was lower than that of CK- MB diagnostic sensitivity(71.8%),but the specificity was better than that of CK- MB,and the diagnosis of cTnl detection window 2 weeks longer than CK- MB,but after 2 weeks both lose their clinical diagnostic significance. Conclusion Children with hand,foot and mouth disease easily merge myocardial damage, dynamic measuring CK- MBand cTnl levels could help early diagnosis of children with hand, foot and mouth disease whether merged myocardial damage, both applications can also complement each other, more timely and accurate reflection of disease progression and recovery, it is worth promoting. Key words: Hand-Foot-And-Mouth Disease; Troponin I; Creatine Kinase, MB Morm