Clinical significance of blood endothelin-1(ET-1),the nitric oxide(NO) and the C reactive protein(CRP) of patient with severe brain injury and the influence of the Mild Hypothermia treatment

林源泉 ,刘文锋 ,贾军 ,张浚

doi:10.3760/cma.j.issn.1008-6706.2004.07.020

Clinical significance of blood endothelin-1(ET-1),the nitric oxide(NO) and the C reactive protein(CRP) of patient with severe brain injury and the influence of the Mild Hypothermia treatment

林源泉 , 刘文锋 + Show 2 more

https://doi.org/10.3760/cma.j.issn.1008-6706.2004.07.020

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Journal: Chinese Journal of Primary Medicine and Pharmacy

Publication Date: Jul 28, 2004

#Normal Temperature Group #Levels Of ET + Show 8 more

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Abstract

目的探讨亚低温治疗重型脑损伤患者的临床疗效及对血内皮素-1(ET-1)、一氧化氮(NO)和C-反应蛋白(CRP)的影响.方法 75例重型脑损伤患者分为两组,亚低温组(40例)与常温组(35例)进行比较.结果入院时两组患者血ET-1、NO和CRP水平均较正常对照组明显升高(P＜0.01);治疗72 h后亚低温组明显低于常温组(P＜0.01).亚低温组病死率10.0%,明显低于常温组(P＜0.05).结论血中ET、NO和CRP水平在重型脑损伤时明显增高,亚低温治疗可降低血中ET-1、NO和CRP水平,改善预后。

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