Clinical significance of anti-cyclic citrullinated peptide antibody in patients with rheumatoid arthritis

Abstract

Objective To study the clinical value of measurement of serum anti-cyclic citrullinated peptile antibody (anti-CCP Ab) in patients with rhematoid arthritis (RA).Methods Serum anti-CCP Ab and RF contents were measured in 45 patients with rhematoid arthritis (RA),22 patients with other disease and 20 healthy people.Anti-CCP Ab was detected by ELISA,and RF was detected by scattering immunoturbidimetric assay.Results The positive rate of anti-CCP Ab was 62.2％ (28/15) in patients with RA,45％ (1/22) in patients with other disease,and 0％ in healthy people.The diagnostic sensitivity of antiCCP was 62.2％,and the diagnostic specificity was 97.6％ for RA.The diagnostic sensitivity of anti-CCP combined with RF was 86.7％ for RA.Conclusions Anti-CCP has good specificity and diagnostic sensitivity for rheumatoid arthritis.Anti-CCP can be regarded as a specific serum marker for RA.Combined detection of serum anti-CCP Ab and RF may be helpful for early diagnosis of rheumatoid arthritis. Key words: Anti-cyclic citrullinated peptide antibody; Rheumatoid arthritis; Rheumatoid factor