Clinical pathology observe of primary malignant melanoma of parotid gland

Abstract

Objective To observe the clinical pathology form of primary malignant melanoma. Methods Specimens were observed by histopathology and immunohistopathologic (S-100, HMB-45, Male-A). Results Tumor islocated on the side, and infiltration of radiofrequent pushed its way to the edge of the Parotid gland tissue. the distribution of dispersoids tumor cells, there were sinusal-like vessel and a little fiber interstitialoma separated, tumor cells have multiformity, nuclear heterotype obvious, fringe cytoplasmic individual tumor cells and the tumor interstitialoma capsulelike brown yellow-brown pigment particles. Innunohistochemistry: The tumor cells were positive for S-100, HMB-45 and Amale-A, weak positive for NSE, Vimentin, but negative for LCA,CD15, CD30, Cytokeratin, EMA, Desmin, SMA, PLAP, Synapsin and Chromogranin A. Conclusion Primary malignant melanoma of the Parotid gland is extremely rare, its histogenesis was disputed, may be the origin of the parotid duct or even DOPA-positive cells in aciner. Key words: Parotid gland; Malignant melanoma; Clinical pathology