Abstract

Objective: to evaluate combinative effect of Kudiezi Injection and low molecular weight heparin calcium in the treatment of acute cerebral infarction. Methods: 72 cases of acute cerebral infarction were randomly divided into two groups, the treatment group of 36 cases were treated with the combination of Kudiezi Injection and low molecular heparin calcium; the other 36 cases in the control group were treated with the combination of Xuesaitong injection and low molecular weight heparin calcium. The degree of neurological deficit score and clinical outcome were respectively evaluated before and after treatment. Results: There are significant differences between the treatment group and the control group in results efficiency. Conclusion: It can improve the curative effect and the prognosis of the patients in the acute stage of cerebral infarction in the combinative treatment of Kudiezi Injection and low molecular weight heparin.

Highlights

  • Objective: to evaluate combinative effect of Kudiezi Injection and low molecular weight heparin calcium in the treatment of acute cerebral infarction

  • 72 cases of acute cerebral infarction were randomly divided into two groups, the treatment group of 36 cases were treated with the combination of Kudiezi Injection and low molecular heparin calcium; the other 36 cases in the control group were treated with the combination of Xuesaitong injection and low molecular weight heparin calcium

  • 低分子肝素钙对体内、外血栓及动、静脉血栓的形成有抑制作用。其作用机制主要是较弱的抗凝血因 子 a(Fa)活性及较强的抗凝血因子 Xa(FXa)活性,因此不能明显延长部分凝血活酶生成时间(KPTT),出血等 副作用小;同时本品不能被血小板第 4 因子中和,通过刺激内皮细胞释放组织因子凝血途径抑制物和纤溶 酶原活化物,对血小板无明显影响[8]。低分子肝素(LMWH)还能促进血液流动,降低高凝状态,增强抗凝 聚和抗血栓作用,促进血管再通,抑制血栓扩大,促进侧枝循环,起到减轻神经功能缺损和挽救缺血半暗 带的作用。血塞通注射液主要含三七总皂甙类物质,能扩张脑血管,降低血黏度,增加脑血流量,促进血 液循环、是临床治疗脑梗死常用中药制剂之一,选其作为对照具有一定的代表性和可比性。本实验显示, 低分子肝素钙联合苦碟子能明显改善血流动力学,降低血液黏度,改善侧支循环和抢救缺血半暗带,从而 改善神经功能缺损程度,与对照组相比差异有显著性。治疗组未发现严重过敏反应及皮肤黏膜、消化道、 颅内出血。提示两者联合治疗急性期脑梗死,疗效显著,价廉方便,安全可靠,值得在临床上推广应用。

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Summary

Introduction

Objective: to evaluate combinative effect of Kudiezi Injection and low molecular weight heparin calcium in the treatment of acute cerebral infarction. Clinical outcome of cerebral infarction in the treatment of Kudiezi Injection Combined with low molecular weight heparin Rizhao City Wulian People's Hospital, Shandong Province 262300,P.

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