Clinical observation of the effect of intranasal corticosteroid plaster in the treatment of allergic rhinoconjunctivitis

Abstract

Objective To investigate the therapeutic effect of short-term application of intranasal corticosteroid ointment in the treatment of allergic rhinoconjunctivitis (ARC). Methods From December 2016 to December 2017, one hundred and sixty-four patients with ARC were diagnosed in the ophthalmological clinic of the Second Affiliated Hospital of Zhengzhou University, and they were divided into observation group (83 cases) and control group(81 cases) according to the digital table.The observation group was treated with tobramycin dexamethasone ophthalmic ointment, and the control group was treated with azzolastine hydrochloride eye drops.The scores of ocular, nasal symptoms and signs were recorded and compared with before treatment, and the clinical effective rates of the two groups were compared. Results After 14 days of treatment, the scores of nasal symptoms and signs in the two groups were significantly lower than those before treatment(all P<0.05). In the observation group, the scores of nasal symptoms and signs after 14 days of treatment were lower than those in the control group, and the differences were statistically significant (t=3.048, P=0.008; t=3.098, P=0.028). The total effective rates of the observation group and control group were 79.51% and 48.19%, respectively, the difference was statistically significant (χ2=18.644, P<0.05). Conclusion The short-term application of intranasal corticosteroid ointment can effectively relieve the clinical symptoms of ARC.The therapeutics is simple and effective, and it is safe and economical.It is very suitable for wide application and popularization in primary clinical hospitals. Key words: Rhinoconjunctivitis; allergic; Allergic conjunctivitis; Allergic rhinitis; Corticosteroid; H1 antihistamines; Intranasal corticosteroid; Drug therapy; Anti-allergic agents; Ointment