Clinical observation of Sanhuang-Jianchi decoction combined with routine treatment of western medicine for treatment of patients with chronic periodontitis

Abstract

Objective To explore the clinical curative effect and safety of Sanhuang-Jianchi decoction combined with routine treatment of western medicine in treatment of patients with chronic periodontitis. Methods According to the randomindicator method, 83 patients with chronic periodontitis conformed to the standard of admission were divided into control group (n=41) and treatment group (n=42). Patients in the control group were treated with periodontal basal treatment and tinidazole, while the treatment group was treated with Sanhuang-Jianchi decoction on the base of control group. The two groups of patients were treated for one month and followed-up for three months. The probing depth (PD), attachment loss (AL) and gingival bleeding index (BI) of two groups of patients were observed before and after treatment. At the same time, the TCM symptom score and gingival sulcus fluid tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6 and IL-8 were detected before and after the treatment. In addition, the incidence of adverse reactions and the recurrence rate in both groups were observed. Results The total clinical effectiveness of the treatment group was 95.2% (40/42) and the control group was 75.6% (31/41). The difference of two groups was statistically significant (χ2=4.363, P=0.037). After treatment, the PD (2.37 ± 0.22 mm vs. 3.04 ± 0.19 mm, t=-14.834), AL (2.53 ± 0.95 mm vs. 3.61 ± 1.05 mm, t=-4.916), BI (1.43 ± 0.13 vs. 2.05 ± 0.17, t=-18.692), the score of ozostomia (1.09 ± 0.51 vs. 1.92 ± 0.64, t=-6.542), Bleeding gums (1.28 ± 0.62 vs. 2.03±0.56, t=-5.779), dry mouth (1.46 ± 0.512 vs. 2.01 ± 0.56, t=-4.680), constipation (1.13 ± 0.47 vs. 1.89 ± 0.54, t=-6.844), tooth non-traumatic (1.06 ± 0.42 vs. 1.73 ± 0.52, t=-6.465), yellow unary (1.17 ± 0.37 vs. 1.81 ± 0.65, t=-5.529) in the treatment group were significantly lower than the control group. The level of TNF-α (3.05 ± 1.02 ng/ml vs. 4.22 ± 1.04 ng/ml, t=-5.174), IL-1β (3.29 ± 1.02 pg/ml vs. 6.24 ± 1.35 pg/ml, t=-11.250), IL-6 (4.15 ± 1.13 pg/ml vs. 6.02 ± 1.24 pg/ml, t=-7.184) and IL-8 (4.03 ± 1.02 pg/ml vs. 6.25 ± 1.19 pg/ml, t=-9.133) of treatment group were significantly lower than control group.The recurrence rate was 5.0% (2/40) in treatment group and 22.6% (7/31) in the control group during the 3 months of follow-up, and the difference was statisticlly significant (χ2=4.877, P=0.027). Conclusions The Sanhuang-Jianchi decoction combined with routine treatment of western medicine can improve the clinical symptoms, restrain the inflammation of gingival sulcus of liquid and reduce recurrence rate. Key words: Chronic periodontitis; Sanhuang-Jianchi decoction; Integrated Chinese traditional and western medicine therapy