Clinical observation of pterygium excision combined with autologous limbal stem cell transplantation in the treatment of 50 cases of primary pterygium

Abstract

Objective To observe the curative effects of pterygium excision combined with autologous limbal stem cell transplantation in the treatment of primary pterygium. Methods 50 cases (72 eyes) of primary pterygium were selected in our hospital.According to the method of random number table, 50 canses were divided into the control group (37 eyes) underwent pterygium excision and the study group (35 eyes) received autologous limbal stem cell transplantation on the basis of the control group, with 25 cases in each, and the efficacy were compare between the two groups. Results The healing time of study group[(3.02±0.37)d] was significantly shorter than in the control group[(6.85±0.48)d](t=2.95, P=0.01) and the recurrence rate (20%) was significantly lower than in the control group (52%) (χ2=10.35, P=0.03), and the postoperative complications rate (8%) was significantly lower than in the control group (36%) (χ2=13.94, P=0.03). Conclusion Compared with pure pterygium excision, pterygium excision combined with autologous limbal stem cell transplantation in the treatment of primary pterygium has higher clinical efficacy, which can effectively shorten the repair time and reduce recurrence rate, with high safety, so it is worthy of further promotion and application in clinic. Key words: Pterygium; Stem cell transplantation; Keratoplasty, penetrating