Clinical observation of nasal spray allergen blocker combined with antihistamines in treatment of allergic rhinitis children

Abstract

Objective:To investigate the clinical effect and safety of nasal spray allergen blocker combined with antihistamines in children with allergic rhinitis. Method:Eighty-four children with mild-severe allergic rhinitis were randomly divided into observation group（42 cases） and control group（42 cases）. Children in control group were treated with azelastine hydrochloride nasal spray, while children in observation group added with nasal spray allergen blocker on the basis of control group. Both groups were treated for 4 weeks. The changes of symptoms and signs integral in both groups were compared and analyzed after 1, 2 and 4 weeks treatment. And Clinical efficacy and adverse reactions between two groups were compared after treatment. Result:Among 4 weeks treatment, the symptoms and signs integral of the two groups showed a significant decreasing trend（P<0.01）. The reduction in the observation group was greater than that in the control group, there were statistical differences in the variation trends of symptoms and signs integral between the two groups（P<0.01, P<0.05）. And there were significant differences in symptoms and signs integral between the two groups（P<0.05）. The total effective rate of observation group（90.5%） was significantly higher than that of control group（64.3%）（P<0.05）. There was no statistically significant difference in the incidence of adverse reactions between the two groups（9.5%vs 4.8%, P>0.05）. Conclusion:The effect of nasal spray allergen blocker combined with antihistamines on allergic rhinitis children is remarkable. They can alleviate the symptoms and signs of allergic rhinitis with rapidity and safety.