Correlation Between Serum 25-Hydroxyvitamin D Levels and Allergic Rhinitis in Children and Adolescents in Korea

Abstract

RationaleVitamin D is known to play a role in the regulation of the immune system and in preventing allergic diseases. The aim of this study was to examine the association between vitamin D and allergic rhinitis (AR) in children and adolescents.MethodsIn total, 100 AR subjects aged 1 to 18 years were enrolled at Severance Children’s Hospital. Serum 25-hydroxyvitamin D (25(OH)D) levels were measured in all the subjects, which were compared with the results of controls, and between the symptom severity group of AR patients. We used the data from 550 subjects of the Korea National Health and Nutrition Examination Survey (KNHANES) with similar ages as a control group. Allergic rhinitis symptom severity was classified by the Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 guidelines. Multivariate logistic regression analysis was used to evaluate the effects of gender, age, and body mass index.ResultsThe mean serum 25(OH)D level was significantly higher in AR patients than in controls (20.68 ± 6.96 vs. 16.23 ± 4.87, p <0.001). The serum 25(OH) concentration associated with increased odds of AR (odds ratio 1.06, 95% CI (1.00 to 1.12), p = 0.039). There was no difference in the 25(OH)D level between the mild and moderate/severe AR patients (21.03 ± 7.08 vs. 20.01 ± 6.78, p = 0.49).ConclusionsElevated serum vitamin D levels may be associated with increased risk of AR in Korean children and adolescents. RationaleVitamin D is known to play a role in the regulation of the immune system and in preventing allergic diseases. The aim of this study was to examine the association between vitamin D and allergic rhinitis (AR) in children and adolescents. Vitamin D is known to play a role in the regulation of the immune system and in preventing allergic diseases. The aim of this study was to examine the association between vitamin D and allergic rhinitis (AR) in children and adolescents. MethodsIn total, 100 AR subjects aged 1 to 18 years were enrolled at Severance Children’s Hospital. Serum 25-hydroxyvitamin D (25(OH)D) levels were measured in all the subjects, which were compared with the results of controls, and between the symptom severity group of AR patients. We used the data from 550 subjects of the Korea National Health and Nutrition Examination Survey (KNHANES) with similar ages as a control group. Allergic rhinitis symptom severity was classified by the Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 guidelines. Multivariate logistic regression analysis was used to evaluate the effects of gender, age, and body mass index. In total, 100 AR subjects aged 1 to 18 years were enrolled at Severance Children’s Hospital. Serum 25-hydroxyvitamin D (25(OH)D) levels were measured in all the subjects, which were compared with the results of controls, and between the symptom severity group of AR patients. We used the data from 550 subjects of the Korea National Health and Nutrition Examination Survey (KNHANES) with similar ages as a control group. Allergic rhinitis symptom severity was classified by the Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 guidelines. Multivariate logistic regression analysis was used to evaluate the effects of gender, age, and body mass index. ResultsThe mean serum 25(OH)D level was significantly higher in AR patients than in controls (20.68 ± 6.96 vs. 16.23 ± 4.87, p <0.001). The serum 25(OH) concentration associated with increased odds of AR (odds ratio 1.06, 95% CI (1.00 to 1.12), p = 0.039). There was no difference in the 25(OH)D level between the mild and moderate/severe AR patients (21.03 ± 7.08 vs. 20.01 ± 6.78, p = 0.49). The mean serum 25(OH)D level was significantly higher in AR patients than in controls (20.68 ± 6.96 vs. 16.23 ± 4.87, p <0.001). The serum 25(OH) concentration associated with increased odds of AR (odds ratio 1.06, 95% CI (1.00 to 1.12), p = 0.039). There was no difference in the 25(OH)D level between the mild and moderate/severe AR patients (21.03 ± 7.08 vs. 20.01 ± 6.78, p = 0.49). ConclusionsElevated serum vitamin D levels may be associated with increased risk of AR in Korean children and adolescents. Elevated serum vitamin D levels may be associated with increased risk of AR in Korean children and adolescents.