Observation of sedative effects of dexmedetomidine nasal drop on infants in CT or MRI examination

Abstract

Objective To observe the sedative effects of dexmedetomidine nasal drop on infants during computed tomography (CT) or magnetic resonance imaging (MRI) examination. Methods Eighty-eight children who underwent CT or MRI and needed sedation in People’sHospital of Hebi from June 2016 to December 2018 were selected and randomly divided into control group and observation group according to the odd and even number method, with 44 cases in each group. Children in control group were sedated with 10% chloral hydrate, and children in observation group were sedated with 1.5 μg/kg dexmedetomidine. The heart rate (HR), mean arterial blood pressure (MAP), saturation of pulse oxygen SpO2 and sedation onset time, awake time, sedation effects score and adverse reactions of the two groups were analyzed before and after sedation. Results After sedation, the HR and MAP in the two groups were decreased first and then increased (P 0.05). After sedation, the sedation onset time and awake time in observation group were significantly shorter than those in control group (P<0.05). The Ramsay scores 20 min after sedation and during examination in observation group were significantly higher than those in control group (P<0.05). After sedation, the incidence of adverse reactions in observation group was significantly lower than that in control group (P<0.05). Conclusions Dexmedetomidine nasal drop has good sedative effects on infants during CT or MRI, and it can sustain hemodynamics stable, with high safety. Key words: Dexmedetomidine nasal drop; Infants; Computed tomography; Magnetic resonance imaging; Sedative effects