Sedation effect and safety of Dexmedetomidine in patients with moderate craniocerebral trauma

Abstract

Objective To explore the sedation effect and safety of Dexmedetomidine in patients with moderate craniocerebral trauma. Methods 62 cases of craniocerebral trauma in our department from May 2015 to June 2018 were selected as the research objects. They were randomly divided into the observation group and the control group after obtaining informed consent from either the patient or an approved surrogate. Patients in observation group were treated with Dexmedetomidine and the other group with diazepam, respectively. We compared the sedation and adverse effect of the two groups before and after the sedation protocol in 10 min, 30 min, 60 min and 120 min. Results After the sedation with Dexmedetomidine in the observation group, the pulse oxygen saturation (SpO2) of patients was significantly higher than that before, while SpO2 of patients in the control group was remarkably higher than that before in 60 and 120 min, respectively (P<0.05). The respiratory rate (RR) of patient in the control group was significantly lower than that in the observation group after sedated in 10 min and 30 min [(30.01±4.26) times/min vs (25.13±3.94) times/min, (27.94±3.35) times/min vs (23.09±4.26) times/min, all P<0.05]. They were significant that onset time (OT) and wakeup timen (WT) min of the observation group after drug withdrawal were shorter than OT and WTof the control group [(68.34±7.01) s vs (285.48±9.59) s, (6.53±1.76) min vs (28.71±2.37) min, P<0.05]. The rate of adverse reaction was 12.90% in the observation group, which obviously lower than 41.93% in the control group (P<0.05). Conclusion The sedation effect and safety of Dexmedetomidine is better than that of diazepam for the patients with moderate craniocerebral trauma. Key words: Moderate craniocerebral trauma; Dexmedetomidine; Sedation