Clinical observation of hyperbaric oxygen with different pressures coupled with comprehensive treatment on extensive gastric ulcer

Abstract

Objective To observe the therapeutic effect of HBO coupled with comprehensive drug treatment on extensive gastric ulcer,with the ultimate aim to select proper therapeutic pressures for enhancement of treatment efficiency.Methods Twenty-four patients diagnosed to be extensive gastric ulcer with electron gastroscope were divided on volunteer basis into the conventional therapy group (with conventional pharmacotherapy),the 0.20 MPa HBO comprehensive treatment group (0.20 MPa HBO treatment coupled with conventional pharmacotherapy) and the 0.25 MPa HBO comprehensive treatment group (0.25 MPa HBO treatment coupled with conventional pharmacotherapy),each consisting of 8 cases.Reexamination with electron gastroscope was performed 8 weeks after treatment intervention,to measure the diameters of the gastric ulcers and evaluate the improvement of clinical symptoms,and finally comparisons were made between groups.Data analysis was dealt with SPSS 11.5 software kit and x2 testing.Results The diameter of the ulcers in all the patients reduced following treatment ( P ＜ 0.01 ).The diameter of ulcers in patients of the 0.25 MPa HBO group reduced more significantly,when compared with the conventional therapy group (P ＜ 0.01 ).Differences could also be seen,when compared with 0.20 MPa HBO group ( P ＜ 0.05 ).The therapeutic effect of 0.25 MPa HBO group was significantly higher than that of the conventional therapy group ( x2 =10.132,P =0.038).Conclusions HBO seemed to have synergistic effect with conventional pharmacotherapy in the treatment of extensive gastric ulcer,accelerating the healing and increasing clinical efficiency.Better results could be achieved with higher oxygen pressure. Key words: Hyperbaric oxygen; Gastric ulcer; Therapeutic effect