Clinical observation of Huangqi injection combined with ribavirin in children with viral myocarditis

Abstract

Objective To evaluate the efficacy of Huangqi injection combined with ribavirin in the treatment of viral myocarditis in children. Methods A total of 89 children with viral myocarditis were randomly divided into treatment group (45 cases) and control group (44 cases) by random number table method. The control group received ribavirin intravenously on the basis of routine treatment, and the treatment group was given Huangqi injection intravenously on the basis of the control group. Both groups were treated continuously for 14 days. The Serum creatine kinase (CK), creatine kinase MB (CK-MB), lactate dehydrogenase (LDH) and aspartate transaminase (AST) were detected by automatic biochemical analyzer. The Serum IL-6, IL-8 and TNF-α were detected by ELISA.The level of CD3+, CD4+, and the ratio of CD4+/CD8+ in peripheral blood was measured by flow cytometry, and the clinical efficacy was evaluated. Results After treatment, the level of serum CK (110.19 ± 12.17 U/L vs. 143.81 ± 17.53 U/L, t=10.530), CK-MB (18.43 ± 4.40 U/L vs. 30.28 ± 5.21 U/L, t=11.602), LDH (139.57 ± 10.36 U/L vs. 162.18 ± 13.22 U/L, t=8.992), AST (24.14 ± 2.19 U/L vs. 35.58 ± 3.34 U/L, t=19.150) in the treatment group were significantly lower than those in the control group (P<0.01). The Serum level of IL-6, IL-8 and TNF-α in the treatment group were significantly lower than those of the control group (t=14.884, 17.043 and 14.364, respectively, P<0.01). The level of CD3+, CD4+, and the ratio of CD4+/CD8+ in peripheral blood of the treatment group was significantly higher than that of the control group (t=6.256, 0.219 and 3.895, respectively, P<0.01). Conclusions The Huangqi injection combined with ribavirin can significantly reduce the degree of myocardial injury and inflammation in children with viral myocarditis, and improve the immune function of children with viral myocarditis. Key words: Myocarditis; Virus diseases; Child; Huangqi injection; Ribavirin; Immunity