Clinical observation of double-way chemotherapy on brucea javanica oil emulsion combined with TP regi-men in treating malignant pleural effusion of NSCLC

Abstract

Objective To evaluate short-term clinical efficacy and adverse effects of brucea javanica oil emulsion(BJOE)combined with TP regimen in treating malignant pleural effusion(MPE)of non-small cell lung cancer(NSCLC)by double-way chemotherapy. Methods Totally 91 patients with MPE of NSCLC diagnosed by pathology were builted into the central venous catheter. The patients were assigned to group A,B and C according to therapies. Group A(21 cases)accepted infusion of BJOE 60mL into thoracic cavity twice a week. Group B(33 cases)accepted TP regime therapy, which included paclitaxel(TAX)intravenous chemotherapy at a dose of 150mg/m2 and cisplatin(DDP)injecting into thoracic cavity at a dose of 60mg＋0.9% sodium chloride injection 30mL in first day, the therapy was repeated every 3 weeks. Group C(38 cases)combined the therapies of group A's and B's. Clinical efficacy and adverse effects were evaluated after 6 weeks. Results The objective response rate(81.6%)for group C was higher than group A or B(χ2＝8.605,P＜0.05),the same result were in CR ratio(55.3%)(χ2＝10.384,P＜0.05)and PD ratio(5.3%)(χ2＝8.649,P＜0.05). There were no serious adverse effects in the three groups. The occurring rate of white blood cell reduction in group A was lower than those of group B and C,there was statistically significance(χ2＝8.999,P＜0.05). Conclusion The efficacy of BJOE combined with TP regimen in treating MPE of NSCLC by double-way chemotherapy is better than that of single chemotherapy or alone intrathoracic treatment, and the adverse effects could be well tolerated. Key words: Pleural effusion, Malignant; Carcinoma, Non-Small-Cell Lung; Brucea javanica oil emulsion