Clinical observation of diabetic foot ulcer treated with Shuxuetong plus external application of deproteinised calf blood serum injection

Abstract

Objective To evaluate the clinical effect of Shuxuetong plus external application of deproteinised calf blood serum injection on diabetic ulcer foot. Methods 60 patients with diabetic foot ulcer were enrolled: 30 cases (treatment group) were randomly assigned to receive deproteinised calf blood serum injection(external use) plus Shuxuetong(iv gtt), and the other 30 cases (control group) received routine western medicine therapy.One course of treatment lasted one month.In addition, both two groups received insulin to control blood sugar and antibiotics to control infection, with foot ulcer treated with debridement, drainage, and removal of necrotic tissue etc. Results Compared with the control group, the effective rate was higher in the treatment group(86.7% vs.60.0%, χ2=5.455, P=0.020). The occurrence time of granulation tissue[(6.60±1.14)d vs.(10.80±2.17)d, t=-3.834, P=0.008]and wound healing time[(23.62±6.14)d vs.(35.65±4.45)d, t=-4.405, P=0.002]were shorter in the treatment group.The wound area in the two groups reduced after treatment, and the wound area in the treatment group reduced significantly[(3.48±1.16)cm2 vs.(8.60±2.51)cm2, t=-4.143, P=0.007]. Conclusion As compared with the routine therapy with western medicine, the combination therapy of deproteinised calf blood serum injection plus Shuxuetong has better efficacy for diabetic ulcer foot. Key words: Diabetic foot; Foot ulcer; Deproteinised calf blood serum injection; Shuxue tong injection