Clinical features of lower respiratory tract multi-drug resistant infections in patients with severe chronic obstructive pulmonary disease

Abstract

Objective To investigate the clinical features of lower respiratory tract multi-drug resistant infections in patients with severe chronic obstructive pulmonary disease(COPD). Methods From December 2014 to December 2015, 140 COPD patients with lower respiratory tract infection were selected, the bacteriological culture of their sputum specimens was made, the clinical symptoms and characteristics, pathogens cultured species and their distribution and the proportion of the top three picks pathogen resistance were observed. Results The main symptoms in the 140 cases patients were cough, sputum and wheezing, both incidence was 100%; secondly, the incidence of dry and wet rales was 98.57%; 96 strains(60.00%) of gram-negative bacteria, 39 strains(24.38%) of gram-positive bacteria, 25 strains(15.62%) of fungi; The first three proportion of pathogens were Pseudomonas aeruginosa (35 strains, 21.88%); Klebsiella pneumoniae (22 strains, 13.75%) and Staphylococcus aureus(20 strains, 12.5%); Pseudomonas aeruginosa pneumonia and Klebsiella pneumoniae were highly susceptible to amikacin and imipenem, and Pseudomonas aeruginosa to cefoperazone sensitivity was higher; Staphylococcus aureus was highly sensitive to imipenem and aztreonam; Three pathogenic bacteria were highly sensitive to imipenem. Conclusions To understand the distribution and drug resistance of pathogenic bacteria in patients with COPD complicated with lower respiratory tract infection is of great significance to the drug intervention of the disease. Key words: Chronic obstructive pulmonary disease; Lower respiratory tract infection; Pathogen; Resistance