Studies of pathogens and drug resistance on the patients of chronic bronchitis with lower respiratory tract infections

Abstract

Objective To examine pathogens and drug resistance in the patients of chronic bronchitis with lower respiratory tract infections, and to provide a sound basis for using antibiotics. Methods A total of 1123 cases of chronic bronchitis with lower respiratory tract infections were included in the study from June 6,2007 to March 31,2010.All cases were supplied by department of respiratory medicine in Beijiao Hospital.Bacterial culture and drug sensitivity test were performed in the sputum of 1123 cases and the results were analyzed. Results Totaled of 387 pathogens had been isolated from sputum bacterial culture in 1123 cases. The results of experiment showed that 220 Gram-negative bacilli, accounting for 56.8%,158 Gram-positive cocci,accounting for 56.8%,9 fungi,accounting for 2.3%,and among the Gram-negative bacilli,51 Escherichia coli,accounting for 23.2%,43 Pseudomonas aeruginosa,accounting for 19.5%,39 Klebsiella pneumoniae,accounting for 17.7%,21 Bowman Acinetobacter,accounting for 9.5%,17 Enterobacter, accounting for 7.7%,10 card Mora bacteria, accounting for 4.5%,9 Enterobacter cloacae, accounting for 4.1%,7 XM Aeromonas,accounting for 3.2%,among the Gram-positive cocci,66 Streptococcus pneumoniae, accounting for 41.8%,48 Staphylococcus epidermidis, accounting for 30.4%,35 Staphylococcus aureus, accounting for 22.2%.Drug sensitivity test showed that the high sensitivity of antibiotics to E.coli were imipenem, cefoperazonesulbactam, cefepime and aztreonam, to Pseudomonas aerugino were saceftazidime, cefoperazone-sulbactam, aztreonam, amikacin, cefepime, imipenem and Stenotrophomonas, to XM Aeromonas were ciprofloxacin and cefoperazonesulbactam, to Bowman Acinetobacter were Imipenem, meropenem, piperacillin-tazobactam and cefoperazone-sulbactam, to Gram-positive cocci were piperacillin-tazobactam, vancomycin, rifamycin and imipenem. Conclusions Gram-negative bacilli and Gram-positive cocci are the major pathogens in the patients of chronic bronchitis with lower respiratory tract infections. The pathogens have a higher resistance to commonly used antibiotics. Antibiotics selection should be based on sputum bacterial culture and drug sensitivity test. Key words: Chronic bronchitis; Lower respiratory tract infection; Drug resistance; Bacterial culture