Analysis of distribution and drug resistance of pathogenic bacteria in patients with lower respiratory tract infection in ICU

Abstract

Objective To investigate the distribution and drug resistance of pathogenic bacteria in hospital ICU patients with lower respiratory tract infection, and provide scientific reference for clinical rational drug use. Methods The strains were identified by VITEK- 32 automatic bacterial identification instrument,the bacterial sensitivity was determined by K- B disk diffusion method,and the statistical analysis was performed by WHONET 5.4 software. Results The total isolated pathogenic bacteria of lower respiratory tract infection in ICU patients was 453 strains.332 strains of gram negative bacteria accounted for 73.3%,and the former three ones were Pseudomonas aeruginosa(115 strains,accounted for 25.4%),Klebsiella pneumonia(90 strains, accounted for 19.8%), Acinetobacter baumannii(38 strains, accounted for 8.4%).102 strains of gram positive bacteria accounted for 22.5%,and the top three were Staphylococcus aureus(31 strains,accounted for 6.8%), coagulase negative Staphylococcus(22 strains, accounted for 4.9%), Enterococcus(18 strains, accounted for 4%). Meropenem,imipenem(Stenotrophomonas maltophilia was excepted), Cefoperazone/ sulbactam and Amikacin were most sensitive against gram negative bacteria; Teicoplanin and vancomycin were highly sensitive against gram positive bacteria. Conclusion The main pathogenic bacteria of respiratory tract infection in ICU patients was gram negative bacilli,which were seriously resistant to commonly used antimicrobial drugs. So strengthening the infection management of ICU and the control for risk factors,and rationally using of antimicrobial drugs has great significance in reducing the drug resistance of pathogenic bacteria rate. Key words: ICU; lower respiratory tract infection; pathogenic bacteria; drug resistance