Clinical features correlated with MMP-9,VEGF expression in invasive pituitary adenoma patients

Abstract

Objective To investigate the relationship in clinical features of invasive pituitary adenoma patients and their aggressive, matrix metalloproteinase 9(MMP-9), vascular endothelial growth factor(VEGF)expression and tumor invasiveness of pituitary adenomas. Methods 96 patients with pituitary adenoma were selected,46 cases of invasive pituitary adenomas,50 cases of non-invasive pituitary adenomas,MMP-9,VEGF expression were detected by immunohistochemical assay, their expression levels were analyzed with tumor invasiveness correlation. Results MMP-9,VEGF expression in invasive pituitary adenomas strongly positive rates were 54.35%,52.17%,the total positive rates were 89.13%,95.65%,which were significantly higher than the non-invasive pituitary adenomas MMP-9,VEGF strong positive expression rate of 16.00%,20.00%,the total positive rates were 44.00%,56.00%(χ2=15.618,9.416,21.631,20.090, all P 0.05);By correlation analysis,invasive pituitary adenoma MMP-9 expression was positively correlated with VEGF levels(r=0.734,P<0.01). Conclusion Invasive pituitary adenomas of MMP-9 and VEGF expression increased, MMP-9 and VEGF can be used as auxiliary judge biological indicators of invasive pituitary adenomas. Key words: Prolactinoma; Matrix metalloproteinase 9; Vascular endothelial growth factors