Clinical features and prognosis of head and neck cancer in patients with esophagus cancer and triple primary carcinoma

Abstract

Objective To investigate the clinical features and prognostic characteristics of head and neck cancer in patients with esophagus cancer and triple primary carcinoma(TPC). Methods A total of 30 patients with head and neck cancer with esophagus cancer TPC were collected in Zhejiang Cancer Hospital from January 2007 to December 2016.The distribution of cancer kinds and the incidence of synchronous and metachronous cancer were described.The clinical characteristics and prognosis were also compared in synchronous and metachronous cancer.The influence of number of hospitalization and different treatments on the survival time were analyzed. Results The TPC of laryngeal pharynx + esophagus + lung and laryngeal pharynx + esophagus + oropharynx had the highest incidence, that was 20.0% in 30 patients(6/30). The second type was laryngeal pharynx+ esophagus+ larynx . Fifteen cases were synchronous cancer and other 15 cases were metachronous cancer.The rate of surgery was 73.3%(11/15), and the number of hospitalization who more or equal than 5 was 73.3%(11/15) in the synchronous cancer.While the rate of surgery was 33.3%(5/15), and the number of hospitalization who more or equal than 5 was 33.3%(5/15) in the metachronous cancer.There were significant differences between synchronous and metachronous cancer(χ2=4.661, 4.661, all P 0.05). Conclusion Head and neck cancer in patients with esophagus cancer TPC can still has a high survival rate through active combined modality therapies, especially in metachronous carcinoma. Key words: Head and neck neoplasms; Esophageal neoplasms; Carcinoma in situ; Neoplasms, multiple primary; Neoplasms, second primary; Antineoplastic protocols; Combined modality therapy; Prognosis