Abstract

Objective To investigate the curative effect of Zhizhukuanzhong capsule combined with Deanxit in the treatment of functional dyspepsia(FD) of spleen-deficiency and qi-stagnation. Methods Seventy-six patients with FD were randomly divided into three groups.A group (24 cases)_was given Zhizhukuanzhong combined with Deanxit, B group (26 cases) was given Zhizhukuanzhong, C group (26 cases) received trimebutine dispersible tablets treatment.After treatment for 8 weeks, the symptoms of indigestion, depressive state and therapeutic effect were observed. Results Before treatment, there were no statistically significant differences in the symptoms of dyspepsia(all P>0.05). After treatment, the symptoms of dyspepsia were improved in different degree, the effective rates of A, B, C three groups were 91.6%, 65.4% and 42.3%, respectively, there was no statistically significant difference between A group and B group(χ2=1.579, P=0.209); there was statistically significant difference between A group and C group(χ2=13.549, P=0.000); there was no statistically significant difference between B group and C group(χ2=2.786, P=0.09). The FD patients complicated with varying degrees of anxiety and depression, there was no statistically significant difference among the three groups before treatment(P>0.05). After treatment, comparison of HAMA and HAMD scores among the three groups: there were statistically significant differences between A group and B group (tHAMA=6.839, tHAMD=4.607, all P 0.05). The adverse reactions of A group were mainly weakness, dizziness, drowsiness, which were alleviated within 2 weeks.The adverse reactions of B group were slight stomach disease and stool frequency increased, which not affected the treatment.The adverse reactions of C group were digestive tract symptoms, which lasted for more than 2 weeks. Conclusion Zhizhukuanzhong capsule combined with Deanxit in the treatment of FD of spleen-deficiency and qi-stagnation can obtain good curative effect, it is safe, convenient, and with minor side effects, good compliance. Key words: Dyspepsia; Flupenthixol; Medicine, Chinese traditional

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