CLINICAL EFFECT OF THE ORAL USE OF METHYL TESTOSTERONE IN EUNUCHOIDISM1

Abstract

THE EFFECTS of the administration of androgens in testicular deficiency have been well described in the past few years, clinically by McCullagh (1) and metabolically by Kenyon et al. (2). Androgens have heretofore been administered by intramuscular injection of testosterone propionate in oil, percutaneously and by subcutaneous pellet implantation (3). Foss (4) and McCullagh (5) described the effects of peroral methyl testosterone in testicular deficiency. The latter concludes that oral methyl testosterone is effective therapy in eunuchoidism and in terms of clinical symptoms its effectiveness as compared to testosterone propionate injections approximates three or four to one. He further states that the increase in urinary androgens following clinically effective doses of the propionate does not occur to the same degree after methyl testosterone. We have used oral methyl testosterone since January, 1940, for disorders in both male and female. Results, however, are being reported only in eunuchoidism since ...